E3 Ligase Ligand-linker Conjugate 133

E3 Ligase Ligand-linker Conjugate 133 is a conjugate of E3 ligase ligand and linker that serve as a key intermediate for the synthesis of complete PROTAC molecule pan-KRAS degrader 4 (HY-168669) [1].

Product Specifications

CAS Number

[3052750-99-6]

UNSPSC

12352101

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-133.html

Smiles

O=C(N(CC1=C2F)C3CCC(NC3=O)=O)C1=CC=C2N(CC4)CCC4CN(CC5)CCC5CC6CCNCC6

Molecular Formula

C30H42FN5O3

Molecular Weight

539.68

References & Citations

[1]Arvinas Operations, Inc., et al. Preparation of pyridopyrimidines as cereblon-based KRas degrading PROTACS and uses related thereto. World Intellectual Property Organization, WO2024159164 A2 2024-08-02

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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