Loreclezole

Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

Product Specifications

CAS Number

[117857-45-1]

Product Name Alternative

R 72063

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/loreclezole.html

Purity

99.97

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

Cl/C(C1=C(C=C(Cl)C=C1)Cl)=C\N2C=NC=N2

Molecular Formula

C10H6Cl3N3

Molecular Weight

274.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91 (10) :4569-73.|[2]Sanna E, et al. Direct activation of GABAA receptors by loreclezole, an anticonvulsant drug with selectivity for the beta-subunit. Neuropharmacology. 1996;35 (12) :1753-60.|[3]Green AR, et al. A behavioural and neurochemical study in rats of the pharmacology of loreclezole, a novel allosteric modulator of the GABAA receptor. Neuropharmacology. 1996;35 (9-10) :1243-50.