IL18R1 Antibody / Interleukin 18 receptor alpha
Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-Gamma production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin s disease cell lines, and does not bind IL-1Alpha or IL-1beta. The association of IL-18 to IL-18R leads to activation of NFkB. At present two subunits of IL-18R have been characterized: IL-18RAlpha and IL-18Rbeta. IL-18RAlpha has been described as the ligand-binding chain and IL-18Rbeta as the signal-transduction chain.
Product Specifications
UniProt
Q13478
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL18R1 antibody.
Clonality
Monoclonal
Clone
IL18R1/7591
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the IL18R1 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG1, kappa
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
MART-1 / Melan-A (M2-7C10), CF594 conjugate, 0.1mg/mL
HLA-Aw32 & HLA-A25 (MHC I) (CATA-1), CF640R conjugate, 0.1mg/mL
Complement C4d (C4D204), CF740 conjugate, 0.1mg/mL
