KR-27370

KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC50: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity[1].br/[1].

Product Specifications

UNSPSC

12352005

Target

PI4K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/kr-27370.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(OC)=CC(CC(NC2=NC(C)=C(C3=CC=C(OC)C(NS(C4=CC=CC=C4)(=O)=O)=C3)S2)=O)=C1

Molecular Formula

C27H27N3O6S2

Molecular Weight

553.65

References & Citations

[1]G Vishakantegowda A, et al. Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents. RSC Med Chem. 2023 Dec 21;15 (2) :704-719.