KR-27370
KR-27370 (compound 7f) is an antiviral agent and selective PI4KIIIβ/PI4KIIIα inhibitor (IC50: 3.1 nM/15.8 nM), against hRV, Ke Saatchivirus and other enteroviruses have inhibitory activity[1].br/[1].
Product Specifications
UNSPSC
12352005
Target
PI4K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kr-27370.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=CC(CC(NC2=NC(C)=C(C3=CC=C(OC)C(NS(C4=CC=CC=C4)(=O)=O)=C3)S2)=O)=C1
Molecular Formula
C27H27N3O6S2
Molecular Weight
553.65
References & Citations
[1]G Vishakantegowda A, et al. Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents. RSC Med Chem. 2023 Dec 21;15 (2) :704-719.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI4KIIIα; PI4KIIIβ
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