Tri-GalNAc biotin
Tri-GalNAc biotin is a biotinylated ASGPR (Asialoglycoprotein receptor) ligand. tri-GalNAc biotin promotes cellular uptake of neutravidin (NA) via ASGPR. tri-GalNAc biotin delivers neutravidin to lysosomes for degradation. tri-GalNAc biotin can be used for research of LYsosome TArgeting Chimera (LYTAC) [1].
Product Specifications
UNSPSC
12352005
Target
LYTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tri-galnac-biotin.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCNC(CCOCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@H]3O)O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4CO)[C@@H]([C@H]([C@H]4O)O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]5CO)[C@@H]([C@H]([C@H]5O)O)NC(C)=O)=O)=O
Molecular Formula
C83H146N14O34S
Molecular Weight
1916.19
References & Citations
[1]Zhou Y, et al Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7 (3) :499-506
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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