Tucatinib (hemiethanolate)
Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.
Product Specifications
CAS Number
1429755-56-5
Product Name Alternative
Irbinitinib (hemiethanolate) ; ARRY-380 (hemiethanolate) ; ONT-380 (hemiethanolate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tucatinib-hemiethanolate.html
Purity
99.97
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC(NC2=C3C=C(NC4=NC(C)(C)CO4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5.CCO
Molecular Formula
C26H24N8O2.1/2C2H6O
Molecular Weight
503.57
Precautions
H302, H315, H319, H335
References & Citations
+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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