Tucatinib (hemiethanolate)

Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.

Product Specifications

CAS Number

[1429755-56-5]

Product Name Alternative

Irbinitinib (hemiethanolate) ; ARRY-380 (hemiethanolate) ; ONT-380 (hemiethanolate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tucatinib-hemiethanolate.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC(NC2=C3C=C(NC4=NC(C)(C)CO4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5.CCO

Molecular Formula

C26H24N8O2.1/2C2H6O

Molecular Weight

503.57

Precautions

H302, H315, H319, H335

References & Citations

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Curated Selection

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