Calcium 2-oxoglutarate

Calcium 2-oxoglutarate is an intermediate in the production of ATP or GTP in the Krebs cycle. Calcium 2-oxoglutarate also acts as the major carbon skeleton for nitrogen-assimilatory reactions. Calcium 2-oxoglutarate is a reversible inhibitor of tyrosinase (IC50=15 mM) [1][2].

Product Specifications

CAS Number

[71686-01-6]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Tyrosinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/calcium-2-oxoglutarate.html

Purity

98.0

Solubility

H2O : 4.85 mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)

Smiles

O=C([O-])C(CCC([O-])=O)=O.[Ca+2]

Molecular Formula

C5H4CaO5

Molecular Weight

184.16

Precautions

H315, H319, H335

References & Citations

[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.