Apatorsen

Apatorsen is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.

Product Specifications

CAS Number

[1002331-21-6]

Product Name Alternative

OGX-427

UNSPSC

12352208

Target

HSP

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apatorsen.html

Purity

98.54

Solubility

H2O : ≥ 20 mg/mL

Smiles

[Apatorsen]

Molecular Formula

C224H304N79O116P19S19

Molecular Weight

7157

References & Citations

[1]Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24 (12) :e1409-e1416. |[2]Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36 (2) :278-287.