GR 82334
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].
Product Specifications
CAS Number
[129623-01-4]
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gr-82334.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]2N(CCC2)C([C@H](CC(O)=O)NC([C@H](C)NC([C@@H]3CCC(N3)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)C(N5[C@]6(CCC5)C(N(CC6)[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O
Molecular Formula
C69H91N15O16
Molecular Weight
1386.55
References & Citations
[1]A Lecci, et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci|[2]Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5 (12) :e15162.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Curated Selection
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