GR 82334

GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist[1]. GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats[1].

Product Specifications

CAS Number

[129623-01-4]

UNSPSC

12352209

Target

Neurokinin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gr-82334.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CC(N)=O)NC([C@H]2N(CCC2)C([C@H](CC(O)=O)NC([C@H](C)NC([C@@H]3CCC(N3)=O)=O)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)C(N5[C@]6(CCC5)C(N(CC6)[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC7=CNC8=CC=CC=C78)=O)=O)=O

Molecular Formula

C69H91N15O16

Molecular Weight

1386.55

References & Citations

[1]A Lecci, et al.Effect of the NK-1 receptor antagonist GR 82,334 on reflexly-induced bladder contractions. Life Sci|[2]Antje Brand, et al. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.PLoS One. 2010 Dec 21;5 (12) :e15162.