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SBI-553

SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2].

Product Specifications

CAS Number

1849603-72-0

UNSPSC

12352005

Hazard Statement

H301, H311, H314, H331

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sbi-553.html

Purity

99.73

Solubility

DMSO : 17 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CN(C1=CC2=C(N=C(N=C2C=C1)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC)CCO

Molecular Formula

C26H31FN4O2

Molecular Weight

450.55

Precautions

H301, H311, H314, H331

References & Citations

[1]Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.|[2]Slosky LM, et al. β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell. 2020 Jun 11;181 (6) :1364-1379.e14.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NTR1

Available Sizes

Frequently Asked Questions

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