SBI-553
SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2].
Product Specifications
CAS Number
[1849603-72-0]
UNSPSC
12352005
Hazard Statement
H301, H311, H314, H331
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sbi-553.html
Purity
99.73
Solubility
DMSO : 17 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CN(C1=CC2=C(N=C(N=C2C=C1)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC)CCO
Molecular Formula
C26H31FN4O2
Molecular Weight
450.55
Precautions
H301, H311, H314, H331
References & Citations
[1]Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.|[2]Slosky LM, et al. β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell. 2020 Jun 11;181 (6) :1364-1379.e14.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NTR1
Available Sizes
Curated Selection
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