Masoprocol
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes[1][2][3].
Product Specifications
CAS Number
27686-84-6
Product Name Alternative
Meso-Nordihydroguaiaretic acid; meso-NDGA
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Lipoxygenase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/masoprocol.html
Purity
99.30
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C=C1C[C@@H](C)[C@@H](C)CC2=CC(O)=C(C=C2)O)=C(C=C1)O
Molecular Formula
C18H22O4
Molecular Weight
302.36
Precautions
H302, H312, H332
References & Citations
[1]Luo J, et al. Masoprocol (nordihydroguaiaretic acid) : a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata) . Eur J Pharmacol. 1998 Apr 3;346 (1) :77-9.|[2]Reed MJ, et al. Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42 (1) :102-6.|[3]Scribner KA, et al. Masoprocol decreases serum triglyceride concentrations in rats with fructose-induced hypertriglyceridemia. Metabolism. 2000 Sep;49 (9) :1106-10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
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