Cycloartenol

Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2].

Product Specifications

CAS Number

[469-38-5]

UNSPSC

12352211

Target

Apoptosis; p38 MAPK

Type

Natural Products

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cycloartenol.html

Purity

99.04

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1(C)[C@@H](O)CC[C@]2(C3)C43CC[C@]5(C)[C@@H]([C@H](C)CC/C=C(C)\C)CC[C@](C)5[C@]4([H])CC[C@@]12[H]

Molecular Formula

C30H50O

Molecular Weight

426.72

References & Citations

[1]Zhang ZL, et al. [Research advance of functional plant pharmaceutical cycloartenol about pharmacological and physiological activity]. Zhongguo Zhong Yao Za Zhi. 2017 Feb;42 (3) :433-437.|[2]Niu H, et al. Cycloartenol exerts anti-proliferative effects on Glioma U87 cells via induction of cell cycle arrest and p38 MAPK-mediated apoptosis. J BUON. 2018 Nov-Dec;23 (6) :1840-1845.