2-Thio-UTP

2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].

Product Specifications

CAS Number

[35763-29-2]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/2-thio-utp.html

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O

Molecular Formula

C9H15N2O14P3S

Molecular Weight

500.21

References & Citations

[1]El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49 (24) :7076-87.|[2]Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10 (2) :457.