2-Thio-UTP
Product Specifications
UNSPSC Description
2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].
Target Antigen
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-thio-utp.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Molecular Weight
500.21
References & Citations
[1]El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87.|[2]Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10(2):457.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116307/2-Thio-UTP-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116307/
Clinical Information
No Development Reported
CAS Number
35763-29-2
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