2-Thio-UTP
2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) [1][2].
Product Specifications
CAS Number
35763-29-2
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-thio-utp.html
Smiles
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
Molecular Formula
C9H15N2O14P3S
Molecular Weight
500.21
References & Citations
[1]El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49 (24) :7076-87.|[2]Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10 (2) :457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y2 Receptor
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Culture Medium for Human Breast Cancer Cells [MX-1]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
AFG-ELL-2859-01 125 mL
Culture Medium for Human Breast Cancer Cells [MX-1]
Sign In for Pricing
View Details AFG-ELL-2859-02 500 mL
Culture Medium for Human Breast Cancer Cells [MX-1]
Sign In for Pricing
View Details GTR15357509 1 Vial
Lentiviral human CD8A sgRNA gene knockout kit - Lentiviral human CD8A sgRNA gene knockout kit (plasmid)
Sign In for Pricing
View Details 