δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, is a potent NaV1.1 agonist with an EC50 of 17nM. δ-Buthitoxin-Hj1a can be used for the Dravet syndrome (DS) research[1].
Product Specifications
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/δ-buthitoxin-hj1a.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC(N)=O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC4=CNC=N4)C(O)=O)=O)NC5=O)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC8=CNC9=CC=CC=C89)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CC(N)=O)C(N[C@H]%11C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%12=O)C(N[C@@H](CC%13=CC=CC=C%13)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC%14=CC=C(C=C%14)O)C(N[C@@H](CSSC[C@@H](C(N[C@H]%15CC%16=CNC%17=CC=CC=C%16%17)=O)NC%11=O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N%18[C@@H](CCC%18)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N%19[C@@H](CCC%19)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N%20[C@@H](CCC%20)C(NCC(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%15=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](CC%21=CNC=N%21)C(NCC(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(NCC(N[C@H]%12CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C326H482N92O96S8
Molecular Weight
7482.39
References & Citations
[1]Chun Yuen Chow, et al. Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs. ACS Pharmacol Transl Sci. 2019 Nov 25;3 (1) :119-134.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
Nav1.1
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