Azosemide

Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC50s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively[1].

Product Specifications

CAS Number

[27589-33-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NKCC

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/azosemide.html

Purity

99.85

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

ClC1=CC(NCC2=CC=CS2)=C(C3=NN=NN3)C=C1S(N)(=O)=O

Molecular Formula

C12H11ClN6O2S2

Molecular Weight

370.84

Precautions

H302, H315, H319, H335

References & Citations

[1]Hampel P, et al. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8 (1) :9877.|[2]Kim EJ, et al. Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagaseanalbuminemic rats. Drug Metab Dispos. 2003 Feb;31 (2) :194-201.