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21-Hydroxyoligomycin A

21-Hydroxyoligomycin A is a potent inhibitor of K-Ras PM localization with an IC50 value of 4.82 nM. 21-Hydroxyoligomycin A has cytotoxicity and can be isolated from Streptomyces[1].

Product Specifications

CAS Number

[102042-09-1]

UNSPSC

12352005

Target

Antibiotic; Ras

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/21-hydroxyoligomycin-a.html

Solubility

10 mM in DMSO

Smiles

C[C@@H]([C@]1([H])OC(/C=C/[C@@H]([C@H]([C@@H](C([C@@H]([C@H]([C@@H]2C)O)C)=O)C)O)C)=O)[C@@](O[C@H]3C[C@H](O)C)(CC[C@@H]3C)O[C@](C[C@H]([C@H](/C=C/C=C\C[C@H]([C@@H]([C@@](O)(C2=O)C)O)C)CC)O)([H])[C@H]1C

Molecular Formula

C45H74O12

Molecular Weight

807.06

References & Citations

[1]Salim AA, et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Org Biomol Chem. 2016 Jan 14;14 (2) :711-715.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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