Voacangine
Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM) . Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM) . Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM) . Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana[1].
Product Specifications
CAS Number
510-22-5
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/voacangine.html
Purity
98.78
Solubility
10 mM in DMSO
Smiles
COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=C(OC)C=C54)C[C@@](C[C@@H]3CC)([H])C1)=O
Molecular Formula
C22H28N2O3
Molecular Weight
368.47
Precautions
H302, H312, H332
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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