Voacangine

Voacangine is an antagonist for TRPV1 and TRPM8 but as an agonist for TRPA1 (EC50=8 μM) . Voacangine competitively blockes capsaicin binding to TRPV1 (IC50=50 μM) . Voacangine competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM) and it shows noncompetitive inhibition against icilin (IC50=7 μM) . Voacangine selectively abrogates chemical agonist-induced TRPM8 activation and did not affect cold-induced activation. Voacangine is an alkaloid isolated from the root bark of Voacanga africana[1].

Product Specifications

CAS Number

[510-22-5]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

TRP Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/voacangine.html

Purity

98.78

Solubility

10 mM in DMSO

Smiles

COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=C(OC)C=C54)C[C@@](C[C@@H]3CC)([H])C1)=O

Molecular Formula

C22H28N2O3

Molecular Weight

368.47

Precautions

H302, H312, H332

References & Citations

[1]Terada Y, et al. Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree. J Nat Prod. 2014;77 (2) :285-297.|[2]Kim Y, et al. A natural small molecule voacangine inhibits angiogenesis both in vitro and in vivo. Biochem Biophys Res Commun. 2012;417 (1) :330-334.