Cyclapolin 9

Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].

Product Specifications

CAS Number

[40533-25-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cyclapolin-9.html

Purity

98.09

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C(C1=[N+]([O-])C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1)N

Molecular Formula

C9H4F3N3O4S

Molecular Weight

307.21

Precautions

H315, H319, H335

References & Citations

[1]Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734.|[2]Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2 (11) :608-17.