TfR-T12

TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

Product Specifications

CAS Number

[344618-30-0]

UNSPSC

12352209

Target

Transferrin Receptor

Type

Peptides

Related Pathways

Apoptosis

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tfr-t12.html

Purity

99.11

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N(CCC1)[C@@H]1C(O)=O)[C@@H](NC([C@H](C(C)C)NC([C@H](CCC2)N2C([C@H](CO)NC([C@@H](NC([C@H](CCSC)NC([C@H](CCC3)N3C([C@H](CCC4)N4C([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC5=CN=CN5)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)=O)=O)CC8=CNC9=CC=CC=C89

Molecular Formula

C71H99N19O15S

Molecular Weight

1490.73

References & Citations

[1]Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68) Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13 (2) :332-41.|[2]Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7 (1) :3487.