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D-Leu-Pro-Arg-Rh110-D-Pro (TFA)

D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity[1].

Product Specifications

UNSPSC

12352209

Target

Factor Xa

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/d-leu-pro-arg-rh110-d-pro-tfa.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

O=C1OC2(C3=CC=C(C=C3OC4=CC(NC([C@@H]5NCCC5)=O)=CC=C24)NC([C@@H](NC([C@H]6N(CCC6)C([C@H](N)CC(C)C)=O)=O)CCCNC(N)=N)=O)C7=CC=CC=C71.O=C(C(F)(F)F)O.[x]

Molecular Formula

C42H51N9O7.xC2HF3O2

Molecular Weight

793.91 (free base)

References & Citations

[1]Lorthiois E, et al. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 Aug 13;63 (15) :8088-8113.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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