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Ketoconazole (Standard)

Ketoconazole (Standard) is the analytical standard of Ketoconazole. This product is intended for research and analytical applications. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.

Product Specifications

CAS Number

65277-42-1

Product Name Alternative

Ketoconazol (Standard) ; R 41400 (Standard)

UNSPSC

12352005

Hazard Statement

H301-H360-H373-H400-H410

Target

Bacterial; Cytochrome P450; Fungal; Ras; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/ketoconazole-standard.html

Smiles

CC(N1CCN(C2=CC=C(OC[C@@H]3O[C@@](CN4C=CN=C4)(C5=CC=C(Cl)C=C5Cl)OC3)C=C2)CC1)=O

Molecular Formula

C26H28Cl2N4O4

Molecular Weight

531.43

Precautions

P260-P264-P270-P273-P280-P330-P391-P405-P501

References & Citations

[1]Seif El-Din SH, et al. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice. Korean J Parasitol. 2013 Apr;51 (2) :165-75.|[2]Eil C. Ketoconazole binds to the human androgen receptor. Horm Metab Res. 1992 Aug;24 (8) :367-70.|[3]Muindi JR et al. CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology. 2010 Sep;151 (9) :4301-12.|[4]Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8 (1) :8161.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Frequently Asked Questions

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