4E1RCat
4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ～4 μM.
Product Specifications
CAS Number
328998-25-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4E1RCat.html
Concentration
10mM
Purity
98.89
Solubility
DMSO : 18.33 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4)=O)C=C1
Molecular Formula
C28H18N2O6
Molecular Weight
478.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Cencic R, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011 Jan 18;108 (3) :1046-51.|[2]Shuda M, et al. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 May 12;112 (19) :5875-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4
Available Sizes
Frequently Asked Questions
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