4E1RCat

4E1RCat is an inhibitor of cap-dependent translation, and inhibits eIF4E:eIF4GI interaction, with an IC50 an of ～4 μM.

Product Specifications

CAS Number

[328998-25-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Eukaryotic Initiation Factor (eIF)

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4E1RCat.html

Concentration

10mM

Purity

98.89

Solubility

DMSO : 18.33 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(N2C(/C(C=C2C3=CC=CC=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4)=O)C=C1

Molecular Formula

C28H18N2O6

Molecular Weight

478.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Cencic R, et al. Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F. Proc Natl Acad Sci U S A. 2011 Jan 18;108 (3) :1046-51.|[2]Shuda M, et al. CDK1 substitutes for mTOR kinase to activate mitotic cap-dependent protein translation. Proc Natl Acad Sci U S A. 2015 May 12;112 (19) :5875-82.