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HSD17B13-IN-65

HSD17B13-IN-65 (Compound 168) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤ 0.1 μM for estradiol. HSD17B13-IN-65 can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].

Product Specifications

CAS Number

2770247-59-9

UNSPSC

12352005

Target

17β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hsd17b13-in-65.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C=C(C=C1Cl)C(NC2=CC=C(C(N=C(N3CC4=CC=CC=C4OC(F)(F)F)C)=C2C3=O)F)=O)Cl

Molecular Formula

C24H15Cl2F4N3O4

Molecular Weight

556.29

References & Citations

[1]Anandan S K, et al. Dichlorophenol HSD17B13 inhibitors and uses thereof. U.S., WO2022103960. 2023-11-28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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