Glycine-13C2,15N, d2

Glycine-13C2,15N, d2 is the deuterium, 13C and 15N labeled Glycine[1]. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[2].

Product Specifications

CAS Number

[1984075-49-1]

UNSPSC

12352211

Target

Endogenous Metabolite; iGluR

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

[15NH2][13C]([2H])([2H])[13C](O)=O

Molecular Formula

13C2H3D2 15NO2

Molecular Weight

80.06

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325 (6104) :529-31.