SMAD4 Antibody
SMAD4 is implicated as a tumor suppressor since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80% of cases of pancreatic adenocarcinoma, but rarely in endometrial (0%), colorectal (0%), ovarian (3%), lung (0%), breast (2%) adenocarcinomas, and malignant melanoma (4%) . SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.
Product Specifications
UniProt
Q13485
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 400-552) from the human protein was used as the immunogen for the SMAD4 antibody.
Clonality
Recombinant
Clone
SMAD4/7905R
Conjugation
Unconjugated
Field of Research
Cancer Biology
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the SMAD4 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG, kappa
Frequently Asked Questions
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