PDCD1 Antibody / PD-1
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
Product Specifications
UniProt
Q15116
Reactivity
Human
Immunogen
A recombinant fragment corresponding to the extracellular domain of human PDCD1 protein was used as the immunogen for the PDCD1 antibody.
Clonality
Recombinant
Clone
PDCD1/7255R
Conjugation
Unconjugated
Field of Research
Cancer Biology; Cell Biology
Purification
Protein A/G affinity
Dilution
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the PDCD1 antibody should be determined by the researcher.
Tested Applications
ELISA, IHC-P
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Rabbit IgG, kappa
Available Sizes
Frequently Asked Questions
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