MG-1102
MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC50s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a Kd of 3.21 mM by surface plasmon resonance (SPR) . MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
[2567913-75-9]
UNSPSC
12352005
Target
MicroRNA; Tau Protein
Type
Reference compound
Related Pathways
Epigenetics; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mg-1102.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C=CC(C2=NNC=C2CN3C=CC=C3C4=NC=CS4)=C5)=C5C=C1
Molecular Formula
C22H18N4OS
Molecular Weight
386.47
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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