MG-1102

MG-1102 is first-in-class dual binder of monomeric tau and pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC50s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a Kd of 3.21 mM by surface plasmon resonance (SPR) . MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD) [1].

Product Specifications

CAS Number

[2567913-75-9]

UNSPSC

12352005

Target

MicroRNA; Tau Protein

Type

Reference compound

Related Pathways

Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mg-1102.html

Solubility

10 mM in DMSO

Smiles

COC1=CC(C=CC(C2=NNC=C2CN3C=CC=C3C4=NC=CS4)=C5)=C5C=C1

Molecular Formula

C22H18N4OS

Molecular Weight

386.47

References & Citations

[1]Moustafa T. Gabr, et al. First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases. Barbault, Chem. Commun., 2020