Nigericin (sodium salt) (Standard)

Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt) . This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[28643-80-3]

UNSPSC

12352005

Target

Antibiotic; Bacterial; NOD-like Receptor (NLR) ; Potassium Channel; Pyroptosis; Reference Standards; Wnt; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Others; Stem Cell/Wnt

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nigericin-sodium-salt-standard.html

Smiles

C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O[Na])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@@]4([H])O[C@@](C)([C@@]5([H])O[C@@]([C@]([C@@H](C[C@@H]6C)C)([H])O[C@]6(O)CO)([H])C[C@H]5C)CC4)C1

Molecular Formula

C40H67NaO11

Molecular Weight

746.94

References & Citations

[1]Zotova L, et al. Novel components of an active mitochondrial K (+) /H (+) exchange. J Biol Chem. 2010 May 7;285 (19) :14399-414. |[2]Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440 (7081) :228-32. |[3]Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118 (5) :381-9. |[4]Xiaoli Zhu, et al. Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms. Front Cell Infect Microbiol. 2022 Dec 20:12:1055929.|[5]Guanzhuang Gao, et al. Evidence of nigericin as a potential therapeutic candidate for cancers: A review. Biomed Pharmacother. 2021 May:137:111262.|[6]Lisha Wu, et al. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers (Basel) . 2023 Jun 16;15 (12) :3221.|[7]Juan Sebastian Yakisich, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol.2017 Mar;39 (3) :1010428317694310.