Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Nigericin (sodium salt) (Standard)

Nigericin (sodium salt) (Standard) is the analytical standard of Nigericin (sodium salt) . This product is intended for research and analytical applications. Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Bacterial; NOD-like Receptor (NLR) ; Potassium Channel; Pyroptosis; Reference Standards; Wnt; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Others; Stem Cell/Wnt

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/nigericin-sodium-salt-standard.html

Smiles

C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C(O[Na])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@@]4([H])O[C@@](C)([C@@]5([H])O[C@@]([C@]([C@@H](C[C@@H]6C)C)([H])O[C@]6(O)CO)([H])C[C@H]5C)CC4)C1

Molecular Formula

C40H67NaO11

Molecular Weight

746.94

References & Citations

[1]Zotova L, et al. Novel components of an active mitochondrial K (+) /H (+) exchange. J Biol Chem. 2010 May 7;285 (19) :14399-414. |[2]Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440 (7081) :228-32. |[3]Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118 (5) :381-9. |[4]Xiaoli Zhu, et al. Nigericin is effective against multidrug resistant gram-positive bacteria, persisters, and biofilms. Front Cell Infect Microbiol. 2022 Dec 20:12:1055929.|[5]Guanzhuang Gao, et al. Evidence of nigericin as a potential therapeutic candidate for cancers: A review. Biomed Pharmacother. 2021 May:137:111262.|[6]Lisha Wu, et al. Nigericin Boosts Anti-Tumor Immune Response via Inducing Pyroptosis in Triple-Negative Breast Cancer. Cancers (Basel) . 2023 Jun 16;15 (12) :3221.|[7]Juan Sebastian Yakisich, et al. Nigericin decreases the viability of multidrug-resistant cancer cells and lung tumorspheres and potentiates the effects of cardiac glycosides. Tumour Biol.2017 Mar;39 (3) :1010428317694310.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100381R/Nigericin-sodium-salt-Standard-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100381R/

Scientific Category

Reference Standards

CAS Number

[28643-80-3]

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rat Monoclonal CD1d Antibody (1B1) [Janelia Fluor 669]
NBP1-43461JF669 0.1 mL

Rat Monoclonal CD1d Antibody (1B1) [Janelia Fluor 669]

Ask
View Details
Rabbit Polyclonal MMP26 Antibody [mFluor Violet 500 SE]
NBP3-00124MFV500 0.1 mL

Rabbit Polyclonal MMP26 Antibody [mFluor Violet 500 SE]

Ask
View Details
Bovine CIAO1 ELISA KIT
ELI-33493b 96 Tests

Bovine CIAO1 ELISA KIT

Ask
View Details
Biotin Conjugated Goat Anti-mouse IgM
NB-SA1058-01 0.25 mg

Biotin Conjugated Goat Anti-mouse IgM

Ask
View Details
Biotin Conjugated Goat Anti-mouse IgM
NB-SA1058-02 0.5 mg

Biotin Conjugated Goat Anti-mouse IgM

Ask
View Details
PE-Linked Monoclonal Antibody to Cardiac Troponin I (cTnI)
MBS2117879-01 0.1 mL

PE-Linked Monoclonal Antibody to Cardiac Troponin I (cTnI)

Ask
View Details