Cucurbitacin I (Standard)

Cucurbitacin I (Standard) is the analytical standard of Cucurbitacin I. This product is intended for research and analytical applications. Cucurbitacin I is a natural selective inhibitor of JAK2/STAT3, with potent anti-cancer activity.

Product Specifications

CAS Number

[2222-07-3]

Product Name Alternative

Elatericin B (Standard) ; JSI-124 (Standard) ; NSC-521777 (Standard)

UNSPSC

12352211

Target

JAK; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cucurbitacin-i-standard.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1=CC[C@@]2([H])[C@@]3(C[C@@H](O)[C@@H]([C@]3(C4)C)[C@@](C)(O)C(/C=C/C(C)(O)C)=O)C)C(C(O)=C[C@@]1([H])[C@]2(C)C4=O)=O

Molecular Formula

C30H42O7

Molecular Weight

514.65

References & Citations

[1]Song J, et al. Cucurbitacin I inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. Oncol Rep. 2015 Apr;33 (4) :1867-71.|[2]Moon Hee Jeong, et al. Cucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads Signalings. PLoS One. 2015 Aug 21;10 (8) :e0136236.