FTO Human Recombinant

<strong>FTO Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2018792_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 56.68 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Fat Mass- and Obesity-Associated Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Khatiwada B, Purslow JA, Underbakke ES, Venditti V. N-terminal fusion of the N-terminal domain of bacterial enzyme I facilitates recombinant expression and purification of the human RNA demethylases FTO and Alkbh5 Protein Expr Purif. 2020 Mar;167:105540._x000D_ 2: Yeo GS. The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition Mol Cell Endocrinol. 2014 Nov;397(1-2):34-41._x000D_ 3: Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, He C. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO FEBS Lett. 2008 Oct 15;582(23-24):3313-9._x000D_ 4: Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL. Regulation of Fto/Ftm gene expression in mice and humans Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1185-96._x000D_ 5: Wu Q, Saunders RA, Szkudlarek-Mikho M, Serna Ide L, Chin KV. The obesity-associated Fto gene is a transcriptional coactivator Biochem Biophys Res Commun. 2010 Oct 22;401(3):390-5._x000D_ 6: Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science. 2007 Nov 30;318(5855):1469-72._x000D_ 7: Jeong HS, Hayashi G, Okamoto A. Diazirine photocrosslinking recruits activated FTO demethylase complexes for specific N(6)-methyladenosine recognition ACS Chem Biol. 2015 Jun 19;10(6):1450-5._x000D_ 8: Zhang B, Zhang Y, Zhang L, Wang J, Li Z, Chen H. Allelic polymorphism detected in the bovine FTO gene Mol Biotechnol. 2011 Nov;49(3):257-62._x000D_ 9: Ming X, Chen S, Li H, Wang Y, Zhou L, Lv Y. m6A RNA Methylation and Implications for Hepatic Lipid Metabolism DNA Cell Biol. 2024 Jun;43(6):271-278._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33690734">10: Chen S, Kumar S, Espada CE, Tirumuru N, Cahill MP, Hu L, He C, Wu L. N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages PLoS Pathog. 2021 Mar 10;17(3):e1009421. </a>_x000D_ _x000D_ <strong>Products Related to FTO Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>