Recombinant Human PLA2R1 Protein

PLA2R1 is a large transmembrane receptor of 180-kDa that belongs to the superfamily of C-type lectins. It was discovered because of its high affinity for secreted phospholipases A2 (sPLA2), enzymes that play a key role in lipid mediator synthesis. Early PLA2R1 physiological roles include the clearance of sPLA2 from the extracellular medium and/or promotion of their actions. Over the last four years, two independent studies suggested that PLA2R1 plays a role in cancer as a tumor gene suppressor and is the major target antigen of auto-immune antibodies involved in idiopathic membranous nephropathy, a severe human kidney disease.

Product Specifications

Product Name Alternative

PLA2R, 180 kDa secretory phospholipase A2 receptor, Secretory phospholipase A2 receptor, PLA2-R, M-type receptor, C-type lectin domain family 13 member C, Soluble PLA2-R, PLA2R1, Soluble PLA2R, CLEC13C

Accession Number

Q13018

Expression System

Confidential

Nature

Recombinant

Applications

As a diagnostic tool for Membranous nephropathy (MN) .

Stability

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.