SOS1-IN-15
SOS1-IN-15 (Compound 37) is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer[1].
Product Specifications
CAS Number
2793404-47-2
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-in-15.html
Purity
98.04
Solubility
DMF : ≥ 100 mg/mL
Smiles
N#CC1(CC1)C(N2CCN3C4=CC5=C(C=C4OC[C@H]3C2)N=C(C)N=C5N[C@H](C)C6=CC=CC(C(F)F)=C6F)=O
Molecular Formula
C28H27F3N6O2
Molecular Weight
536.55
References & Citations
[1]Zhang S, et al. Design and Structural Optimization of Orally Bioavailable SOS1 Inhibitors for the Treatment of KRAS-Driven Carcinoma. J Med Chem. 2022 Nov 17.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
Frequently Asked Questions
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