Tat-beclin 1 (TFA)
Tat-beclin 1 TFA, a peptide derived from a region of the autophagy protein (beclin 1), is a potent inducer of autophagy and interacts with negative regulator of autophagy, GAPR-1 (GLIPR2) . Tat-beclin 1 TFA decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) [1].
Product Specifications
UNSPSC
12352209
Target
Autophagy; CHIKV; HIV
Type
Peptides
Related Pathways
Anti-infection; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tat-beclin-1-tfa.html
Solubility
H2O
Smiles
Molecular Formula
C166H252F3N57O47
Molecular Weight
3855.12
References & Citations
[1]Sanae Shoji-Kawata, et al. Identification of a Candidate Therapeutic Autophagy-Inducing Peptide. Nature. 2013 Feb 14;494 (7436) :201-6.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HIV-1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items