SFOM-0046
Product Specifications
UNSPSC Description
SFOM-0046 arrests cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into γ-H2AX. SFOM-0046 induces DNA damages. SFOM-0046 is a potent anticancer agent[1].
Target Antigen
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sfom-0046.html
Smiles
O=S(C1=CC=C(C=C1)NC(NCC)=O)(OC2=CC=CC=C2CC)=O
Molecular Weight
348.42
References & Citations
[1]Joris Pauty, et al. Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks. Sci Rep. 2016 Mar 22:6:23302.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121777/SFOM-0046-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121777/
Clinical Information
No Development Reported
CAS Number
1383607-61-1
Curated Selection
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