SFOM-0046

SFOM-0046 arrests cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into γ-H2AX. SFOM-0046 induces DNA damages. SFOM-0046 is a potent anticancer agent[1].

Product Specifications

CAS Number

[1383607-61-1]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sfom-0046.html

Smiles

O=S(C1=CC=C(C=C1)NC(NCC)=O)(OC2=CC=CC=C2CC)=O

Molecular Formula

C17H20N2O4S

Molecular Weight

348.42

References & Citations

[1]Joris Pauty, et al. Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks. Sci Rep. 2016 Mar 22:6:23302.