Vitamin K1-d7

Vitamin K1-d7 is the deuterium labeled Vitamin K1. Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism[1][2].

Product Specifications

CAS Number

[1373049-34-3]

Product Name Alternative

Phylloquinone-d7; Phytomenadione-d7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.0

Solubility

10 mM in DMSO|DMF : ≥ 25mg/mL|DMSO : ≥ 25mg/mL|Ethanol : ≥ 25mg/mL

Smiles

O=C1C(C([2H])([2H])[2H])=C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(C2=C1C([2H])=C([2H])C([2H])=C2[2H])=O

Molecular Formula

C31H39D7O2

Molecular Weight

457.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Basset GJ, et al. Phylloquinone (Vitamin K1) : Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22.|[3]Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;2015:296721.|[4]Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96 (5) :1113-8.|[5]Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53 (2) :108-13.|[6]Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46 (4) :409-12.