Dabuzalgron
Product Specifications
UNSPSC Description
Dabuzalgron (Ro 115-1240) is an orally active and selective α-1A adrenergic receptor agonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function[1].
Target Antigen
Adrenergic Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis;GPCR/G Protein;Neuronal Signaling
Field of Research
Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dabuzalgron.html
Purity
98.72
Solubility
DMSO : 26 mg/mL (ultrasonic)
Smiles
CS(=O)(NC1=C(Cl)C=CC(OCC2=NCCN2)=C1C)=O
Molecular Weight
317.79
References & Citations
[1]Beak J, et al. An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity. JACC Basic Transl Sci. 2017 Feb;2(1):39-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117071/Dabuzalgron-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117071/Dabuzalgron-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
219311-44-1
Available Sizes
Curated Selection
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