Peramivir (trihydrate)

Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes[1][2][3].

Product Specifications

CAS Number

[1041434-82-5]

Product Name Alternative

RWJ 270201 trihydrate; BCX 1812 trihydrate

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ERK; IKK; Influenza Virus; JNK; p38 MAPK; STAT

Type

Reference compound

Related Pathways

Anti-infection; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Peramivir-trihydrate.html

Purity

98.30

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@]([C@H](C(CC)CC)NC(C)=O)([H])[C@H](NC(N)=N)C[C@@H]1C(O)=O.[H]O.[H]O.[H]O

Molecular Formula

C15H34N4O7

Molecular Weight

382.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang C, et al. Peramivir, an anti-influenza virus drug, exhibits potential anti-cytokine storm effects [J]. Frontiers in Immunology, 2022, 13: 856327.|[2]Pascua P N Q, et al. Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection [J]. Scientific reports, 2017, 7 (1) : 7345.|[3]Alame M M, et al.. Peramivir: a novel intravenous neuraminidase inhibitor for treatment of acute influenza infections [J]. Frontiers in microbiology, 2016, 7: 450.