SK-3-91

SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases) . SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396) ; Blue: E3 ligase ligand (HY-131717) ; Black: Linker (HY-140819) . The E3 ligase ligand and linker can form a conjugate (HY-169397) ) [1][2].

Product Specifications

CAS Number

[2769753-23-1]

UNSPSC

12352005

Target

PROTACs; YTHDF

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sk-3-91.html

Purity

98.33

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1C2C(NC(CC2)=O)=O)C3=C(NCC(NCCOCCN4CCN(C5=CC=C(NC6=NC(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)=C(Cl)C=N6)C=C5)CC4)=O)C=CC=C3C1=O

Molecular Formula

C42H47ClN10O8S

Molecular Weight

887.40

References & Citations

[1]Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.|[2]Goebel GL, et al. Profiling Cellular Morphological Changes Induced by Dual-Targeting PROTACs of Aurora Kinase and RNA-Binding Protein YTHDF2. Chembiochem. 2024 Oct 1;25 (19) :e202400183.