SK-3-91
Product Specifications
UNSPSC Description
SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases)[1]. SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) TAE648 (HY-169396), the E3 ubiquitin ligase ligand (blue part) Thalidomide-NH-CH2-COOH (HY-131717) and the PROTAC linker (Bromo-PEG1-C2-azide) (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397).
Target Antigen
PROTACs
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sk-3-91.html
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=C(NCC(NCCOCCN4CCN(C5=CC=C(NC6=NC(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)=C(Cl)C=N6)C=C5)CC4)=O)C=CC=C3C1=O
Molecular Weight
887.40
References & Citations
[1]Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137341/SK-3-91-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137341/SK-3-91-SDS-MedChemExpress.pdf
CAS Number
2769753-23-1
Available Sizes
Curated Selection
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