AS2717638

AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3) . AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2].

Product Specifications

CAS Number

[2148339-28-8]

Product Name Alternative

OPC-14857 (Standard); DM-14857 (Standard),OPC-14857; DM-14857

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/AS2717638.html

Purity

99.85

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

O=C1N(C=C(C2=C1C=C(C(OC)=C2)OC)C(N3CCCCC3)=O)C4=NOC5=C4C=C(C=C5)C

Molecular Formula

C25H25N3O5

Molecular Weight

447.48

References & Citations

[1]Murai N, et al. Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents. Neuropharmacology. 2017 Nov;126:97-107.|[2]Joshi L, et al. Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. Int J Mol Sci. 2021 Aug 7;22 (16) :8519.