CCT374705
CCT374705 is an orally active BCL6 inhibitor (IC50 = 4.8 nM) with potent antiproliferative effects in vitro. CCT374705 effectively inhibits tumor growth in a lymphoma xenograft mouse model[1].
Product Specifications
CAS Number
2640647-90-9
UNSPSC
12352005
Target
BCL6
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct374705.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(C=C(NC3=C(Cl)C(F)=NC=C3)C=C2)C4=C1OCC(F)(F)[C@H](C5CC5)N4
Molecular Formula
C21H18ClF3N4O2
Molecular Weight
450.84
References & Citations
[1]Harnden AC, et al. Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones. J Med Chem. 2023 Apr 27;66 (8) :5892-5906.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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