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Dronedarone (Hydrochloride)

Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.

Product Specifications

CAS Number

141625-93-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Potassium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Dronedarone-Hydrochloride.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CS(=O)(NC1=CC=C(OC(CCCC)=C2C(C3=CC=C(OCCCN(CCCC)CCCC)C=C3)=O)C2=C1)=O.[H]Cl

Molecular Formula

C31H45ClN2O5S

Molecular Weight

593.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Bogdan R, et al. Effect of?dronedarone?on Na+, Ca2+ and HCN channels. Naunyn Schmiedebergs Arch Pharmacol.?2011 Apr;383 (4) :347-56.?|[2]Doggrell SA, et al. Dronedarone: an amiodarone analogue. Expert Opin Investig Drugs. 2004 Apr;13 (4) :415-26.|[3]Manning AS, et al. SR 33589, a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. J Cardiovasc Pharmacol. 1995 Sep;26 (3) :453-61.|[4]Breitenstein A, et al. Dronedarone reduces arterial thrombus formation. Basic Res Cardiol. 2012 Nov;107 (6) :302.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Adv Mater. 2024 Jun;36 (24) :e2311760.|Int J Mol Sci. 2025 May 1;26 (9) :4304.|bioRxiv. 2025 Nov 21:2025.11.20.689520.

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