Dolastatin 10

Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

Product Specifications

CAS Number

[110417-88-4]

Product Name Alternative

DLS 10; NSC 376128

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Dolastatin-10.html

Purity

98.11

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C([C@H](C)[C@H]([C@]1([H])CCCN1C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)C)=O)OC)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3

Molecular Formula

C42H68N6O6S

Molecular Weight

785.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5 (3) :525-31.|[2]Pettit GR, et al. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications ofdolastatin 10. J Nat Prod. 2011 May 27;74 (5) :962-8.|[3]Brentuximab vedotin. Drugs R D. 2011;11 (1) :85-95.