Levoleucovorin
Levoleucovorin (Levofolinic acid) is the pharmacologically active levoisomer of racemic leucovorin. Levoleucovorin can be used as a rescue agent after high-dose Methotrexate (HY-14519) therapy, and in combination with fluorouracil for the research of advanced metastatic colorectal cancer[1].
Product Specifications
CAS Number
[68538-85-2]
Product Name Alternative
Levofolinic acid; Levofolene
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/levoleucovorin.html
Purity
98.53
Solubility
DMSO : 35 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic; adjust pH to 11 with 1 M NaOH)
Smiles
O=CN1C2=C(NC(N)=NC2=O)NC[C@@H]1CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
Molecular Formula
C20H23N7O7
Molecular Weight
473.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Chuang VT, et al. Levoleucovorin as replacement for leucovorin in cancer treatment. Ann Pharmacother. 2012 Oct;46 (10) :1349-57.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
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